Insight into performance of nitrogen removal enhanced by adding lactic acid-rich food waste fermentation liquid as carbon source in municipal wastewater treatment.

Lactic acid-rich fermentation liquid (LAFL) of food waste is found to act as a promising alternative carbon source for nitrogen removal in wastewater treatment. Here, LAFL was employed to investigate its impacts on nitrogen removal during raw municipal wastewater treatment with a comparison to sodium acetate (NaAc). Results indicated that nitrogen removals were comparable when incorporated with LAFL and NaAc (92.89 % v.s. 91.23 %). Unlike the utilization of NaAc, using LAFL could avoid suppressing the relative abundance of the nitrification genes and thus pose a negative risk to nitrogen removal during prolonged operation. The introduction of LAFL increased the stability and robustness of the functional microbial community and effectively reduced excess activated sludge (AS) generation by 109 % compared to NaAc addition, consequently enhancing nitrogen removal but diminishing the treatment cost. In general, LAFL exhibits prospective engineering application potentials and economic advantages in improving nitrogen removal by AS process.

A novel approach for purifying food waste anaerobic digestate through bio-conditioning dewatering followed by activated sludge process: A case study.

Although anaerobic digestion is the mainstream technology for treating food waste (FW), the high pollutant concentration in the resultant food waste anaerobic digestate (FWAD) often poses challenges for the subsequent biochemical treatment such as activated sludge process. In this study, taking a typical FW treatment plant as an example, we analyzed the reasons behind the difficulties in treating FWAD and tested a novel process called as bio-conditioning dewatering followed by activated sludge process (BDAS) to purify FWAD. Results showed that high concentrations of suspended solids (SS) (16439 ± 475 mg/L), chemical oxygen demand (COD) (24642 ± 1301 mg/L), and ammonium nitrogen (NH4+-N) (2641 ± 52 mg/L) were main factors affecting the purification efficiency of FWAD by the conventional activated sludge process. By implementing bio-conditioning dewatering for solid-liquid separation, near 100% of SS and total phosphorus (TP), 90% of COD, 38% of total nitrogen (TN), and 37% of NH4+-N in the digestate could be effectively removed or recovered, consequently generating the transparent filtrate with relatively low pollution load and dry sludge cake (<60% of moisture content). Furthermore, after ammonia stripping and biochemical treatment, the effluent met the relevant discharge standards regulated by China, with the concentrations of COD, TN, NH4+-N, and TP ranging from 151 to 405, 10-56, 0.9-31, and 0.4-0.8 mg/L, respectively. This proposed BDAS approach exhibited stable performance and low operating costs, offering a promising solution to purify FWAD in practical engineering and simultaneously realize resource recovery.

Aeration pre-treatment role in improving the performance of bio-conditioning dewatering of food waste anaerobic digestate.

Bio-conditioning dewatering followed by activated sludge process (BDAS) is a promising technology for purifying food waste anaerobic digestate (FWAD). However, the bio-conditioning dewatering efficiency is often affected by FWAD properties and ambient temperature. Here, we firstly reported that aeration pre-treatment of FWAD played an important role in improving the bio-conditioning dewatering performance of FWAD. The study found that the accumulated carbonate (CO32-) in FWAD severely affected the flocculation of Fe-containing flocculant formed in microbial fermentation liquor due to the competitive consumption of the flocculant by CO32-. The capillary suction time (CST) and specific resistance to filtration (SRF) of the bio-conditioned FWAD increased from initial 77.8 s and 2.0 × 1012 m/kg to 122.7 s and 3.4 × 1012 m/kg, respectively, within 1 day of aeration. Prolonged aeration pre-treatment of FWAD could reduce its CO32- concentration and total alkalinity. Additionally, the aeration pre-treatment simultaneously decreased the proportion of macromolecular organic matter that hindered dewatering and the content of total solids (TS) and hydrophilic protein-like substances in FWAD. After 20 days of aeration followed by bio-conditioning, the CST and SRF reduced to final 36.5 s and 2.3 × 1011 m/kg, respectively, indicating a substantial improvement in dewatering performance. Successive forced aeration combined with the addition of CaCl2 to eliminate adverse factors mainly CO32- was a feasible and cost-effective strategy to realize bio-conditioning dewatering of FWAD in less than 2 days and a lower reagents dose of bio-conditioning, which was helpful in the engineering application of the novel BDAS process for FWAD purification.

Ultralight and Robust Covalent Organic Framework Fiber Aerogels.

Shaping covalent organic frameworks (COFs) into macroscopic objects with robust mechanical properties and hierarchically porous structure is of great significance for practical applications but remains formidable and challenging. Herein, a general and scalable protocol is reported to prepare ultralight and robust pure COF fiber aerogels (FAGs), based on the epitaxial growth synergistic assembly (EGSA) strategy. Specifically, intertwined COF nanofibers (100-200 nm) are grown in situ on electrospinning polyacrylonitrile (PAN) microfibers (≈1.7 µm) containing urea-based linkers, followed by PAN removal via solvent extraction to obtain the hollow COF microfibers. The resultant COF FAGs possess ultralow density (14.1-15.5 mg cm-3 ) and hierarchical porosity that features both micro-, meso-, and macropores. Significantly, the unique interconnected structure composed of nanofibers and hollow microfibers endows the COF FAGs with unprecedented mechanical properties, which can fully recover at 50% strain and be compressed for 20 cycles with less than 5% stress degradation. Moreover, the aerogels exhibit excellent capacity for organic solvent absorption (e.g., chloroform uptake of >90 g g-1 ). This study opens new avenues for the design and fabrication of macroscopic COFs with excellent properties.

Ultrathin nitrogen-doped carbon Ti3C2Tx-TiN heterostructure derived from ZIF-8 nanoparticles sandwiched MXene for high-performance capacitive deionization.

Rational design of high-performance electrode materials is crucial for enhancing desalination performance of capacitive deionization (CDI). Here, ultrathin nitrogen-doped carbon/Ti3C2Tx-TiN (NC/MX-TiN) heterostructure was developed by pyrolyzing zeolite imidazolate framework-8 (ZIF-8) nanoparticles sandwiched MXene (ZSM), which were formed by assembling ultrafine ZIF-8 nanoparticles with size of 20 nm on both sides of MXene nanosheets. The introduction of ultrasmall ZIF-8 particles allowed for in situ nitridation of the MXene during pyrolysis, forming consecutive TiN layers tightly connected to the internal MXene. The two-dimensional (2D) heterostructure exhibited remarkable properties, including high specific surface area and excellent conductivity. Additionally, the resulting TiN demonstrated exceptional redox capability, which significantly enhanced the performance of CDI and ensured cycling stability. Benefiting from these advantages, the NC/MX-TiN exhibited a maximum adsorption capacity of 45.6 mg g-1 and a steady cycling performance in oxygenated saline water over 50 cycles. This work explores the rational design and construction of MXene-based 2D heterostructure and broadens new horizons for the development of novel CDI electrode materials.

Engineering Multinanochannel Polymer-Intercalated Graphene Oxide Membrane for Strict Volatile Sieving in Membrane Distillation.

Graphene oxide (GO) membranes enabled by subnanosized diffusion channels are promising to separate small species in membrane distillation (MD). However, the challenge of effectively excluding small volatiles in MD persists due to the severe swelling and subsequent increase in GO interlamination spacing upon direct contact with the hot feed. To address this issue, we implemented a design in which a polymer is confined between the GO interlaminations, creating predominantly 2D nanochannels centered around 0.57 nm with an average membrane pore size of 0.30 nm. Compared to the virginal GO membrane, the polymer-intercalated GO membrane exhibits superior antiswelling performance, particularly at a high feed temperature of 60 °C. Remarkably, the modified membrane exhibited a high flux of approximately 52 L m-2 h-1 and rejection rates of about 100% for small ions and 98% for volatile phenol, with a temperature difference of 40 °C. Molecular dynamics simulations suggest that the sieving mechanisms for ions and volatiles are facilitated by the narrowed nanochannels within the polymer network situated between the 2D nanochannels of GO interlaminations. Concurrently, the unrestricted permeation of water molecules through the multinanochannel GO membrane encourages high-flux desalination of complex hypersaline wastewater.

Enhanced dewatering extent of sludge by Fe3O4-driven heterogeneous Fenton.

Homogeneous Fenton (Fe2+/H2O2) serves as a high-efficiency conditioning method for sludge dewatering due to the generation of strong oxidizing hydroxyl radicals (OH). However, high dose of ferric salts produces iron-rich dewatered sludge and decrease sludge organic matters, which will not be conducive to the subsequent disposal and reutilization. Considering advantages of Fe3O4 as heterogeneous Fenton catalyst, Fe3O4-activated H2O2 (Fe3O4 + H2O2) in this study was adopted to improve sludge deep-dewatering. Reduction efficiency of the bound water (71.3 %) after Fe3O4 + H2O2 treatment (after a reaction time of 30 min) were much higher than those in the Fe2++H2O2 treatment. Especially, the moisture content of treated sludge cake by Fe3O4 + H2O2 remarkably decreased from 86.4 % to 61.3 %. Improvement mechanism of sludge dewatering after Fe3O4 + H2O2 treatment mainly included electrostatic neutralization, reactive radical oxidation, and skeleton building by analysis of contribution factors. The generation of H+ in acidification could neutralize the negatively charged compounds to promote sludge hydrophobicity. Meanwhile reactive radicals generated from Fe3O4 + H2O2 destroyed sludge extracellular polymeric substances and cell structure to release intracellular water. Furthermore, Fe3O4 as a skeleton builder could reconstruct destructive sludge flocs and form new dewatering channels. Finally, low Fe leaching content and recoverability of Fe3O4 effectively will decrease environmental implication.

Iron containing sludge-derived carbon towards efficient peroxymonosulfate activation: Active site synergy, performance and alternation mechanism.

Converting industrial sludge into catalytic materials for water purification is a promising approach to simultaneously realize effective disposal of sludge and resource of water. However, manipulating the high efficiency remains a huge challenge due to the difficulty in the active sites control of the sludge. Herein, we proposed a constitutive modulation strategy by the combination of hydrothermal and pyrolysis (HTP) for the fabrication of defects-assistant Fe containing sludge-derived carbon catalysts on upgrading performance in peroxymonosulfate (PMS) activation for pollutant degradation. Adjustable defects on dyeing sludge-derived carbon catalysts (DSCC) were achieved by introducing oxygen or nitrogen functional precursors (hydroquinone or p-phenylenediamine) during hydrothermal processes and by further pyrolysis, where O was detrimental while N was beneficial to defect generation. Compared to the DSCC with less defects (DHSC-O), the defect-rich sample (DHSC-2N) exhibited superior catalytic performance of PMS activation for bisphenol A (BPA) elimination (k = 0.45 min-1, 2.52 times of DHSC-O), as well as 81.4% total organic carbon (TOC) removal. Meanwhile, the degradation capacity was verified in wide pH range (2.1-8.1) and various aqueous matrices, reflecting the excellent adaptability and anti-interference performance. Furthermore, the continuous-flow experiments on industrial wastewater showed synchronous BPA and chemical oxygen demand (COD) removal, implying great potential for practical application. Solid electron paramagnetic resonance (EPR) and 57Fe Mösssbauer spectra analysis indicated that the defects acted as secondary active sites for Fe sites, which were beneficial to accelerating the electron transfer process. The only Fe active sites preferred the radical pathway. The controllable reaction tendency provides possibilities for the on-demand design of sludge-based catalysts to meet the requirements of practical wastewater treatment under Fenton-like reaction.

Dyeing sludge-derived biochar for efficient removal of antibiotic from water.

Adsorption is one of the most effective methods for ecotoxic antibiotics removal, while developing high-performance adsorbents with excellent adsorption capacity is indispensable. As the unavoidable by-product of wastewater, sewage sludge has dual properties of pollution and resources. In this study, dyeing sludge waste was converted to biochar by KOH activation and pyrolysis, and used as an efficient adsorbent for aqueous antibiotics removal. The optimized dyeing sludge-derived biochar (KSC-8) has excellent specific surface area (1178.4 m2/g) and the adsorption capacity for tetracycline (TC) could reach up to 1081.3 mg/g, which is four and five times higher than those without activation, respectively. The PSO (pseudo-second-order) kinetic model and the Langmuir isotherm model fitted better to the experimental data. The obtained KSC-8 has stabilized adsorption capacity for long-term fixed-bed experiments, and maintained 86.35% TC removal efficiency after five adsorption-regeneration cycles. The adsorption mechanism involves electrostatic attraction, hydrogen bonding, π-π interactions and pore filling. This work is a green and eco-friendly way as converting the waste to treat waste in aiming of simultaneous removal of antibiotics and resource recovery of dyeing sludge.

Enhancing Uranium Removal with a Titanium-Incorporated Zirconium-Based Metal-Organic Framework.

The urgent need to efficiently and rapidly decontaminate uranium contamination in aquatic environments underscores its significance for ecological preservation and environmental restoration. Herein, a series of titanium-doped zirconium-based metal-organic frameworks were meticulously synthesized through a stepwise process. The resultant hybrid bimetallic materials, denoted as NU-Zr-n%Ti, exhibited remarkable efficiency in eliminating uranium (U (VI)) from aqueous solution. Batch experiments were executed to comprehensively assess the adsorption capabilities of NU-Zr-n%Ti. Notably, the hybrid materials exhibited a substantial increase in adsorption capacity for U (VI) compared to the parent NU-1000 framework. Remarkably, the optimized NU-Zr-15%Ti displayed a noteworthy adsorption capacity (∼118 mg g-1) along with exceptionally rapid kinetics at pH 4.0, surpassing that of pristine NU-1000 by a factor of 10. This heightened selectivity for U (VI) persisted even when diverse ions exist. The dominant mechanisms driving this high adsorption capacity were identified as the robust electrostatic attraction between the negatively charged surface of NU-Zr-15%Ti and positively charged U (VI) species as well as surface complexation. Consequently, NU-Zr-15%Ti emerges as a promising contender for addressing uranium-laden wastewater treatment and disposal due to its favorable sequestration performance.

TIMP2 ameliorates blood-brain barrier disruption in traumatic brain injury by inhibiting Src-dependent VE-cadherin internalization.

Blood-brain barrier (BBB) disruption is a serious pathological consequence of traumatic brain injury (TBI), for which there are limited therapeutic strategies. Tissue inhibitor of metalloproteinase-2 (TIMP2), a molecule with dual functions of inhibiting MMP activity and displaying cytokine-like activity through receptor binding, has been reported to inhibit VEGF-induced vascular hyperpermeability. Here, we investigate the ability of TIMP2 to ameliorate BBB disruption in TBI and the underlying molecular mechanisms. Both TIMP2 and AlaTIMP2, a TIMP2 mutant without MMP-inhibiting activity, attenuated neurological deficits and BBB leakage in TBI mice; they also inhibited junctional protein degradation and translocation to reduce paracellular permeability in human brain microvascular endothelial cells (ECs) exposed to hypoxic plus inflammatory insult. Mechanistic studies revealed that TIMP2 interacted with α3ß1 integrin on ECs, inhibiting Src activation-dependent VE-cadherin phosphorylation, VE-cadherin/catenin complex destabilization, and subsequent VE-cadherin internalization. Notably, localization of VE-cadherin on the membrane was critical for TIMP2-mediated EC barrier integrity. Furthermore, TIMP2-mediated increased membrane localization of VE-cadherin enhanced the level of active Rac1, thereby inhibiting stress fiber formation. All together, our studies have identified an MMP-independent mechanism by which TIMP2 regulates EC barrier integrity after TBI. TIMP2 may be a therapeutic agent for TBI and other neurological disorders involving BBB breakdown.

Omics analyses of Rehmannia glutinosa dedifferentiated and cambial meristematic cells reveal mechanisms of catalpol and indole alkaloid biosynthesis.

BACKGROUND: Rehmannia glutinosa is a rich source of terpenoids with a high medicinal reputation. The present study compared dedifferentiated cells (DDCs) and cambial meristematic cells (CMCs) cell cultures of R. glutinosa for terpenoid (catalpol) and indole alkaloid (IA) biosynthesis. In this regard, we used widely targeted metabolomics and transcriptome sequencing approaches together with the comparison of cell morphology, cell death (%), and catalpol production at different time points. RESULTS: We were able to identify CMCs based on their morphology and hypersensitivity to zeocin. CMCs showed higher dry weight content and better catalpol production compared to DDCs. The metabolome analysis revealed higher concentrations of IA, terpenoids, and catalpol in CMCs compared to DDCs. The transcriptome sequencing analysis showed that a total of 27,201 genes enriched in 139 pathways were differentially expressed. The higher catalpol concentration in CMCs is related to the expression changes in genes involved in acetyl-CoA and geranyl-PP biosynthesis, which are precursors for monoterpenoid biosynthesis. Moreover, the expressions of the four primary genes involved in monoterpenoid biosynthesis (NMD, CYP76A26, UGT6, and CYP76F14), along with a squalene monooxygenase, exhibit a strong association with the distinct catalpol biosynthesis. Contrarily, expression changes in AADC, STR, and RBG genes were consistent with the IA biosynthesis. Finally, we discussed the phytohormone signaling and transcription factors in relation to observed changes in metabolome. CONCLUSIONS: Overall, our study provides novel data for improving the catalpol and IA biosynthesis in R. glutinosa.

Umbilical cord mesenchymal stem cell-conditioned medium inhibits microglial activation to ameliorate neuroinflammation in amyotrophic lateral sclerosis mice and cell models.

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease for which few effective therapeutic strategies are available. Increasing evidence indicates that neuroinflammation plays a significant role in ALS pathogenesis. Mesenchymal stem cell (MSC)-based therapy has been proposed for the treatment of neurodegenerative diseases, including ALS. In this study, we first demonstrated that systemic administration of conditioned medium derived from umbilical cord MSCs (UCMSC-CM) extends the lifespan of transgenic SOD1-G93A mice, a well-characterized model of familial ALS. Moreover, UCMSC-CM inhibits microglial activation and astrogliosis and alleviates the inflammatory milieu by reducing the release of proinflammatory cytokines and the expression of iNOS in the spinal cord. Using BV-2 cells overexpressing the SOD1-G93A mutant as an ALS cellular model, we uncovered that UCMSC-CM also suppresses the lipopolysaccharide (LPS)-induced inflammatory response, including reduced expression of proinflammatory cytokines and iNOS. Importantly, by culturing astrocytes alone in microglia-conditioned medium (MCM) or together with microglia in a transwell coculture system, we found that UCMSC-CM modulates the secretome of microglia exposed to inflammatory stimuli, thereby preventing the conversion of astrocytes to the A1 neurotoxic phenotype. This study revealed the anti-inflammatory properties of UCMSC-CM and its regulatory effect on glial activation in the treatment of neuroinflammation in ALS, providing strong evidence for the clinical application of UCMSC-CM.

Promoting dewatering efficiency of sludge by bioleaching coupling chemical flocculation.

In recent years, bioleaching has emerged as a cost-effective technology for enhancing the dewaterability of sludge. However, the lengthy treatment time involved in sludge bioleaching processes limits daily treatment capacity for sludge. Here, a novel approach was developed through a short time of sludge bioleaching with A. ferrooxidans LX5 (A. f) and A. thiooxidans TS6 (A. t) followed by polyferric sulfate (PFS) flocculation (A. f + A. t + PFS). After 12.5 h of the A. f + A. t + PFS treatment (30% A. f, 10% A. t, 40 mg/g DS S0, 60 mg/g DS FeSO4•7H2O, and 120 mg/g DS PFS), the reduction efficiency of specific resistance to filtration (SRF) and sludge cake moisture content reached 94.0% and 11.6%, respectively, which were comparable to the results achieved through 24 h of completed bioleaching treatment. In pilot-scale applications, the mechanical dewatering performance was notably improved following A. f + A. t + PFS treatment, with the low moisture content of the treated sludge cake (∼59.2%). This study provides new insights into the A. f + A. t + PFS process and holds potential for developing efficient and promising sludge dewatering strategies in engineering application.

Patient engagement during the transition from nondialysis-dependent chronic kidney disease to dialysis: A meta-ethnography.

INTRODUCTION: Patient engagement, encompassing both patient experience and opportunities for involvement in care, has been associated with increased patient satisfaction and the overall quality of care. Despite its importance, there is limited knowledge regarding patient engagement in the transition from nondialysis-dependent chronic kidney disease (CKD) to dialysis-dependent treatment. This systematic review employs meta-ethnography to synthesize findings from qualitative studies examining patients' experiences of engagement during this transition, with the aim of developing a comprehensive theoretical understanding of patient engagement in the transition from nondialysis-dependent CKD to dialysis. METHODS: A systematic search of six databases, namely the Cochrane Library, PsycINFO, Scopus, Embase, PubMed and Web of Science was conducted to identify eligible articles published between 1990 and 2022. Meta-ethnography was utilized to translate and synthesize the findings and develop a novel theoretical interpretation of 'patient engagement' during the transition to dialysis. RESULTS: A total of 24 articles were deemed eligible for review, representing 21 studies. Patient engagement during a transition to dialysis was found to encompass three major domains: psychosocial adjustment, decision-making and engagement in self-care. These three domains could be experienced as an iterative and mutually reinforcing process, guiding patients toward achieving control and proficiency in their lives as they adapt to dialysis. Additionally, patient engagement could be facilitated by factors including patients' basic capability to engage, the provision of appropriate education, the establishment of supportive relationships and the alignment with values and resources. CONCLUSIONS: The findings of this review underscore the necessity of involving patients in transitional dialysis care, emphasizing the need to foster their engagement across multiple domains. Recommendations for future interventions include the provision of comprehensive support to enhance patient engagement during this critical transition phase. Additional research is warranted to explore the effects of various facilitators at different levels. PATIENT OR PUBLIC CONTRIBUTION: The studies included in our review involved 633 participants (547 patients, 14 family members, 63 healthcare providers and 9 managers). Based on their experiences, views and beliefs, we developed a deeper understanding of patient engagement and how to foster it in the future.

Elemental sulfur redox bioconversion for selective recovery of phosphorus from Fe/Al-bound phosphate-rich anaerobically digested sludge: Sulfur oxidation or sulfur reduction?

The biological oxidation of elemental sulfur (S0) to sulfate and the reduction of S0 to sulfide provide a potential route for extracting and reclaiming phosphorus (P) from anaerobically digested sludge (ADS). However, the treatment performance, stability, and cost-effectiveness of the two opposing bioprocesses based on S° for selective P recovery from ADS remain unclear. This study aimed to compare the roles of S0-oxidizing bacteria (S0OB) and S0-reducing bacteria (S0RB) in liberating insoluble P from ADS through single-batch and consecutive multibatch experiments. Changes in P speciation in the sludge during the biological extraction processes were analyzed by using complementary sequential extraction and P X-ray absorption near-edge spectroscopy. Results showed that S0OB treatment extracted more phosphate from the sludge compared with S0RB treatment, but it also released a considerable amount of metal cations (e.g., heavy metals, Mg2+, Al3+, Ca2+) and negatively affected sludge dewaterability due to intense sludge acidification and cell lysis. At pH 1.2, the S0OB treatment released 92.9% of P from the sludge, with the dissolution of HAP, Fe-PO4, Mg3(PO4)2, and P-fehrrihy contributing 26.8%, 22.1%, 12.8%, and 10.5%, respectively. The S0RB treatment released 63.6% of P from the sludge at pH 7.0, with negligible dissolution of metal cations, thereby avoiding costly purification of the extract and alkali neutralization for pH adjustment. This treatment involved the replacement of phosphates bounded with Fe-PO4 (FePO4 and P-fehrrihy) and Al-PO4 (P-Alumina and AlPO4) with biogenic sulfides, with contributions of 72.7%, and 20.9%, respectively. Consecutive bioprocesses for P extraction were achieved by recirculating the treated sludge. Both S0OB and S0RB treatments did not affect the extent of sludge dewatering but considerably weakened the dewatering rate. The S0OB-treated sludge exhibited prolonged filtration time (from 3010 s to 9150 s) and expressing time (from 795 s to 4690 s) during compression dewatering. After removing metal cations using cation exchange resin (CER) and neutralizing using NaOH, a vivianite product Fe3(PO4)2·8H2O (purity: 84%) was harvested from the S0OB-treated extract through precipitation with FeSO4·7H2O. By contrast, a vivianite product Fe3(PO4)2·8H2O (purity: 81%) was directly obtained from the S0RB-treated extract through precipitation with FeSO4·7H2O. Ultimately, 79.8 and 57.9wt% of P were recovered from ADS through S0OB extraction-CER purification-alkali neutralization-vivianite crystallization, and S0RB extraction-vivianite crystallization, respectively. Collectively, biological S0 reduction is more applicable than biological S0 oxidation for selectively reclaiming P from Fe/Al-associated phosphate-rich ADS due to better cost-effectiveness and process simplicity. These findings are of significance for developing sludge management strategies to improve P reclamation with minimal process inputs.

Schwertmannite-based heterogeneous Fenton for enhancing sludge dewaterability over a wide pH range.

Fe-based Fenton technology is commonly used to enhance sludge dewaterability, but it requires subsequent neutralization, resulting in excessive chemical consumption. In this study, we investigated the feasibility of using schwertmannite-composited Fe3O4 (Sch/Fe3O4) as a heterogeneous Fenton catalyst to enhance sludge dewaterability without the need for pH adjustment. A high reduction efficiency of sludge specific resistance to filtration (94.4%), moisture content (11.4%) and bound water (45.5%) after Sch/Fe3O4 +H2O2 treatment at initial pH 7.5 were obtained, suggesting that Sch/Fe3O4 +H2O2 posed good dehydration performance without any acidification. SO42- and H+ generation in Sch/Fe3O4 system played an important role in sludge pH decrease, which facilitated sludge cell lysis, intracellular water release, and provided a suitable pH for Fenton reaction. Reactive species (•OH, •O2-, and 1O2) from Sch/Fe3O4 +H2O2 could effectively destroy sludge EPS, releasing more bound water. Additionally, the negatively charged compounds were neutralized by dissolved Fe2+/Fe3+. Sch/Fe3O4, as a skeleton builder, rearranged the dissociative sludge flocs to improve the incompressibility and permeability of sludge cake. Finally, sludge treated with Sch/Fe3O4 +H2O2 achieved organic matters reserve, heavy metals reduction, further benefiting the final disposal.

Risk factors and a new nomogram for predicting brain metastasis from lung cancer: a retrospective study.

Objective: This study aims to establish and validate a new nomogram for predicting brain metastasis from lung cancer by integrating data. Methods: 266 patients diagnosed as lung cancer between 2016 and 2018 were collected from Guangdong Academy of Medical Sciences. The first 70% of patients were designated as the primary cohort and the remaining patients were identified as the internal validation cohort. Univariate and multivariable logistics regression were applied to analyze the risk factors. Independent risk factors were used to construct nomogram. C-index was used to evaluate the prediction effect of nomogram.100 patients diagnosed as lung cancer between 2018 and 2019 were collected for external validation cohorts. The evaluation of nomogram was carried out through the distinction and calibration in the internal validation cohort and external validation cohort. Results: 166 patients were diagnosed with brain metastasis among the 266 patients. The gender, pathological type (PAT), leukocyte count (LCC) and Fibrinogen stage (FibS) were independent risk factors of brain metastasis. A novel nomogram has been developed in this study showed an effective discriminative ability to predict the probability of lung cancer patients with brain metastasis, the C-index was 0.811. Conclusion: Our research provides a novel model that can be used for predicting brain metastasis of lung cancer patients, thus providing more credible evidence for clinical decision-making.

Interlayered Interface of a Thin Film Composite Janus Membrane for Sieving Volatile Substances in Membrane Distillation.

Hypersaline wastewater treatment using membrane distillation (MD) has gained significant attention due to its ability to completely reject nonvolatile substances. However, a critical limitation of current MD membranes is their inability to intercept volatile substances owing to their large membrane pores. Additionally, the strong interaction between volatile substances and MD membranes underwater tends to cause membrane wetting. To overcome these challenges, we developed a dual-layer thin film composite (TFC) Janus membrane through electrospinning and sequential interfacial polymerization of a polyamide (PA) layer and cross-linking a polyvinyl alcohol/polyacrylic acid (PP) layer. The resulting Janus membrane exhibited high flux (>27 L m-2 h-1), salt rejection of ∼100%, phenol rejection of ∼90%, and excellent resistance to wetting and fouling. The interlayered interface between the PA and PP layer allowed the sieve of volatile substances by limiting their dissolution-diffusion, with the increasing hydrogen bond network formation preventing their transport. In contrast, small water molecules with powerful dynamics were permeable through the TFC membrane. Both experimental and molecular dynamics simulation results elucidated the sieving mechanism. Our findings demonstrate that this type of TFC Janus membrane can serve as a novel strategy to design next-generation MD membranes against volatile and non-volatile contaminants, which can have significant implications in the treatment of complex hypersaline wastewater.